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KMID : 1143620220260010042
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Korean Journal of Nuclear Medicine Technology
2022 Volume.26 No. 1 p.42 ~ p.46
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Verification of the upper limit of results through dilution tests for RIA test
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Lee Geun-Ui
Choi Jin-Ju
Lee Young-Ji
Yoo Seon-Hee
Lee Sun-Ho
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Abstract
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Purpose: In the meantime, there have been not many samples that require dilution, and it has been difficult for the examiner to set an appropriate dilution multiple for RIA test item and report the results. Accordingly, it was judged that it was necessary to set the maximum dilution multiple for each test and to verify the upper limit of the clinical reportable range. Therefore, in this study, the maximum dilution multiple for each RIA test was set and the upper limit of the clinical reportable range was verified accordingly
Materials and Methods: Among all RIA tests conducted at Asan Medical Center, the study treated on 30 types of tests which also conduct the dilution test. Data from March to July 2021 were collected and analyzed. The study was conducted on samples subjected to serial dilutions such as X2, X4 or X10, X102, X103, X104, X105.
Results: Among a total of 30 test types, 18 test types have more than 5 N values in the tolerance range of 80~120%. As a result of the verification of maximum dilution multiples, the test set to 104 is ??-fetoprotein and thyroglobulin, and the test set to 103 is CA-125, CEA, and ??-hCG, and the test set to 102 is Free PSA, PSA, CA15-3, SCC, Ferritin, PTH, Cortisol, and Calcitonin. Tests set to 10 include three categories: ??2-Microglobulin, C-peptide, and Testosterone.
Conclusion: It is expected that it will contribute to improving the quality of nuclear medicine blood tests as the results of dilution experiments can be reported quickly and accurately through the verification of the clinical reportable range.
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KEYWORD
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Clinical reportable range, Upper limit verification, Maximum dilution multiple(ratio)
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